Influence of demographic factors and serotonin transporter-linked polymorphic region (5-HTTLPR) variants on major depression in a northeastern Thai population

Abstract

Background: Several lines of evidence suggest that the serotonergic system may be involved in the etiology of major depressive disorder (MDD). Objective: Investigate a potential association between the functional polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) and MDD in a northeastern Thai population, and explore the involvement of demographic characteristics in this disorder. Methods: One hundred eighty seven patients with MDD and 207 healthy controls were recruited from the same geographical area into the study. The 5-HTTLPR genotypes were determined using polymerase chain reaction (PCR) and analyzed statically. Results: Significant demographic differences between the two groups were observed, which included age, marital status, occupation, educational background, income, and alcohol use. The allele frequencies of the 5- HTTLPR polymorphism in our studied population were relatively near those of Asian populations, especially Chinese, which was regarded as enormously distinct from those of Caucasians. Nevertheless, our present study found no significant association between this polymorphism and MDD with respect to either genotype distributions or allele frequencies. Conclusion: No involvement of the 5-HTTLPR polymorphism was suggested, but demographic features in MDD were highlighted with respect to this studied population.