dc.contributor.author |
Adchara Prommaban |
|
dc.contributor.author |
Suwannee Sriyab |
|
dc.contributor.author |
Pachabadee Marsup |
|
dc.contributor.author |
Waranya Neimkhum |
|
dc.contributor.author |
Jakkapan Sirithunyalug |
|
dc.contributor.author |
Songyot Anuchapreeda |
|
dc.contributor.author |
Chaiwat To-anun |
|
dc.contributor.author |
Wantida Chaiyana |
|
dc.contributor.author |
อัจฉรา พรมมาแบน |
|
dc.contributor.author |
สุวรรณี ศรียาบ |
|
dc.contributor.author |
วรัญญา เนียมขำ |
|
dc.contributor.author |
จักรพันธ์ ศิริธัญญาลักษณ์ |
|
dc.contributor.author |
ทรงยศ อนุชปรีดา |
|
dc.contributor.author |
ชัยวัฒน์ โตอนันต์ |
|
dc.contributor.author |
วรรธิดา ชัยญาณะ |
|
dc.contributor.author |
ปชาบดี มาทรัพย์ |
|
dc.contributor.other |
Chiang Mai University. Faculty of Pharmacy |
th |
dc.contributor.other |
Chiang Mai University. Faculty of Pharmacy |
th |
dc.contributor.other |
Chiang Mai University. Faculty of Pharmacy |
th |
dc.contributor.other |
Huachiew ChalermprakietUniversity. Faculty of Pharmaceutical Sciences |
th |
dc.contributor.other |
Chiang Mai University. Research Center of Pharmaceutical Nanotechnology |
th |
dc.contributor.other |
Chiang Mai University. Faculty of Associated Medical Sciences |
th |
dc.contributor.other |
Chiang Mai University. Faculty of Agriculture |
th |
dc.contributor.other |
Chiang Mai University. Faculty of Pharmacy |
th |
dc.date.accessioned |
2024-03-07T13:41:15Z |
|
dc.date.available |
2024-03-07T13:41:15Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Pharmaceutical Biology 60,1 (2022) : 225-234. |
th |
dc.identifier.other |
https://doi.org/10.1080/13880209.2021.2025255 |
|
dc.identifier.uri |
https://has.hcu.ac.th/jspui/handle/123456789/1829 |
|
dc.description |
สามารถเข้าถึงบทความฉบับเต็มได้ที่
https://www.tandfonline.com/doi/epdf/10.1080/13880209.2021.2025255?needAccess=true |
th |
dc.description.abstract |
Context Cordyceps militaris and Isaria tenuipes (Cordycipitaceae) are high-value fungi that are used for health-promoting food supplements. Since laboratory cultivation has begun for these fungi, increased output has been achieved. Objective This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of C. militaris and I. tenuipes. Materials and methods The antioxidative potential of 10% v/v aqueous infused extract from each fungus was separately investigated using 2,2-azinobis(3-ethylbenzo-thiazoline-6-sulphonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant ability, and ferric thiocyanate methods. The inhibition against MMP-1, elastase, and hyaluronidase were determined to reveal their anti-wrinkle potential. Anti-tyrosinase activities were determined. Results C. militaris and I. tenuipes extracts were found to contain a wide range of bioactive compounds, including phenolics, flavonoids, and adenosine. A correlation was discovered between the chemical compositions and their biological activities. The extract from I. tenuipes fruiting body (IF) was highlighted as an extraordinary elastase inhibitor (IC50 = 0.006 ± 0.004 mg/mL), hyaluronidase inhibitor (IC50: 30.3 ± 3.2 mg/mL), and antioxidant via radical scavenging (ABTS IC50: 0.22 ± 0.02 mg/mL; DPPH IC50: 0.05 ± 0.02 mg/mL), thereby reducing ability (EC1: 95.3 ± 4.8 mM FeSO4/g extract) and lipid peroxidation prevention (IC50: 0.40 ± 0.11 mg/mL). IF had a three-times higher EC1 value than ascorbic acid and significantly higher elastase inhibition than epigallocatechin gallate. Discussion and conclusions IF is proposed as a powerful natural extract with antioxidant and anti-wrinkle properties; therefore, it is suggested for further use in pharmaceutical, cosmeceutical, and nutraceutical industries. |
th |
dc.language.iso |
th |
th |
dc.subject |
คอร์ไดซิปิน |
th |
dc.subject |
Cordycepin |
th |
dc.subject |
อะดีโนซีน |
th |
dc.subject |
Adenosine |
th |
dc.subject |
อายุวัฒนะ |
th |
dc.subject |
Anti-aging |
th |
dc.subject |
ผิวหนัง -- รอยย่น |
th |
dc.subject |
Skin -- Wrinkles |
th |
dc.subject |
Anti-wrinkle |
th |
dc.title |
Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes |
th |
dc.type |
Article |
th |