Abstract:
In this research,three ester derivatives of cinnamoc acid and benzendiol were synthesized via eseriification reaction between cinnamic acid with excess oxalyl chloride and benzenediol. The derivatives were purified by column chromatography and elucidated by FT-IR, NMR and mass spectroscopy. In vitro antioxidant activity and tyrosinase inhibitory were measured. Compound 5c exhibited the highest DPPH scavenging activity with the IC50 value of 56.35 μg/ml, followed by compound 5a (26.10 mg/ml) and compound 5b (46.90 mg/ml). Compound 5c also showed the highest inhibitory activity against tyrosinase enzyme with the IC50 value of 24.01 μg/ml compared to compound 5b (153.70 μg/ml), and compound 5a (179.62 μg/ml) respectively. The CC50 values of compound 5a, 5b, and 5c were higher than 100 μg/ml and lower than that of hydroquinone in the REMA adday the human skin fibroblast cells.
