Please use this identifier to cite or link to this item: https://has.hcu.ac.th/jspui/handle/123456789/1816
Title: Anti-Inflammatory and Antimicrobial Activities of Fermented Ocimum sanctum Linn. Extracts against Skin and Scalp Microorganisms
Authors: Wantida Chaiyana
Chanun Punyoyai
Suwannee Sriyab
Adchara Prommaban
Sasithorn Sirilun
Jakkrawut Maitip
Panuwan Chantawannakul
Waranya Neimkhum
Songyot Anuchapreeda
วรรธิดา ชัยญาณะ
สุวรรณี ศรียาบ
อัจฉรา พรมมาแบน
ศศิธร ศิริลุน
จักราวุธ ไม้ทิพย์
ภาณุวรรณ จันทวรรณกูร
วรัญญา เนียมขำ
ทรงยศ อนุชปรีดา
Chiang Mai University. Faculty of Pharmacy
Chiang Mai University. Faculty of Pharmacy
Chiang Mai University. Faculty of Pharmacy
Chiang Mai University. Faculty of Pharmacy
Chiang Mai University. Faculty of Pharmacy
King Mongkut's University of Technology North Bangkok. Faculty of Science, Energy and Environment
Chiang Mai University. Faculty of Science
Huachiew Chalermprakiet University. Faculty of Pharmaceutical Sciences
Chiang Mai University. Faculty of Pharmacy
Keywords: Anti-inflammatory agents
Antibiotics
แอนติบอดีย์
สารต้านการอักเสบ
Ocimum sanctum Linn.
กระเพรา
Scalp
หนังศีรษะ
Issue Date: 2021
Citation: Chemistry & Biodiversity 19, 2 December 2021
Abstract: This study aimed to revealed anti-inflammatory and antimicrobial activities of fermented Ocimum sanctum Linn. (FE). The fermentation process with Lactobacillus plantarum was compared with the solvent extraction methods. Antimicrobial activity against the growth of Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans, and Malassezia furfur was investigated via broth dilution method. High performance thin layer chromatography was used to determine eugenol content. The anti-inflammation was investigated by means of nuclear factor kappa B (NF-κB) expression inhibition by Western blot analysis. FE yielded the highest amount (11.93 % w/w), the highest eugenol content (39.3±12.6 % w/w), and the highest antimicrobial activities comparing to the extracts obtained from the solvent extractions. The fungal inhibition against M. furfur 656 was equivalent to that of ketoconazole. Furthermore, the bacterial inhibition on S. aureus and S. epidermidis was compared to that of Penicillin G at minimum inhibitory concentration (MIC) of 0.125 mg/mL and 0.25 mg/mL, respectively. Interestingly, FE had lower MIC and minimum bactericidal concentration against P. acnes than Penicillin G and also possessed comparable anti-inflammatory activity to indomethacin with the NF-κB suppression of 42.7±4.6 %. Therefore, FE are potentially natural anti-inflammation and antimicrobial agents for topical applications in the pharmaceutical and cosmetic industries.
Description: สามารถเข้าถึงบทความฉบับเต็มได้ที่ https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202100799
URI: https://has.hcu.ac.th/jspui/handle/123456789/1816
Appears in Collections:Pharmaceutical Sciences - Artical Journals

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