Please use this identifier to cite or link to this item: https://has.hcu.ac.th/jspui/handle/123456789/1821
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dc.contributor.authorBrinda Balasubramanian-
dc.contributor.authorSimran Venkatraman-
dc.contributor.authorKyaw Zwar Myint-
dc.contributor.authorSucheewin Krobthong-
dc.contributor.authorPatompon Wongtrakoongate-
dc.contributor.authorJittiyawadee Sripa-
dc.contributor.authorPanthip Rattanasinganchan-
dc.contributor.authorPornphimon Metheenukul-
dc.contributor.authorRutaiwan Tohtong-
dc.contributor.authorสุชีวัน กรอบทอง-
dc.contributor.authorปฐมพล วงศ์ตระกูลเกตุ-
dc.contributor.authorจิตติยวดี ศรีภา-
dc.contributor.authorปานทิพย์ รัตนศิลป์กัลชาญ-
dc.contributor.authorพรพิมล เมธีนุกูล-
dc.contributor.authorฤทัยวรรณ โต๊ะทอง-
dc.contributor.otherMahidol University. Faculty of Scienceth
dc.contributor.otherMahidol University. Faculty of Science. Graduate Program in Molecular Medicineth
dc.contributor.otherMahidol University. Faculty of Scienceth
dc.contributor.otherMahidol University. Faculty of Scienceth
dc.contributor.otherMahidol University. Faculty of Scienceth
dc.contributor.otherUbon Ratchathani University. College of Medicine and Public Healthth
dc.contributor.otherHuachiew Chalermprakiet University. Faculty of Medicine Technologyth
dc.contributor.otherKasetsart University. Faculty of Veterinary Technologyth
dc.contributor.otherMahidol University. Faculty of Scienceth
dc.date.accessioned2024-03-07T04:12:35Z-
dc.date.available2024-03-07T04:12:35Z-
dc.date.issued2022-
dc.identifier.citationMolecules 2022, 27(14), 4664; https://doi.org/10.3390/molecules27144664th
dc.identifier.otherhttps://doi.org/10.3390/molecules27144664-
dc.identifier.urihttps://has.hcu.ac.th/jspui/handle/123456789/1821-
dc.descriptionสามารถเข้าถึงบทความฉบับเต็มได้ที่ https://www.mdpi.com/1420-3049/27/14/4664th
dc.description.abstractCholangiocarcinoma (CCA) is a heterogenous group of malignancies in the bile duct, which proliferates aggressively. CCA is highly prevalent in Northeastern Thailand wherein it is associated with liver fluke infection, or Opisthorchis viverrini (OV). Most patients are diagnosed in advanced stages, when the cancer has metastasized or severely progressed, thereby limiting treatment options. Several studies investigate the effect of traditional Thai medicinal plants that may be potential therapeutic options in combating CCA. Galangin is one such herbal flavonoid that has medicinal properties and exhibits anti-tumor properties in various cancers. In this study, we investigate the role of Galangin in inhibiting cell proliferation, invasion, and migration in OVinfected CCA cell lines. We discovered that Galangin reduced cell viability and colony formation by inducing apoptosis in CCA cell lines in a dose-dependent manner. Further, Galangin also effectively inhibited invasion and migration in OV-infected CCA cells by reduction of MMP2 and MMP9 enzymatic activity. Additionally, using proteomics, we identified proteins affected post-treatment with Galangin. Enrichment analysis revealed that several kinase pathways were affected by Galangin, and the signature corroborated with that of small molecule kinase inhibitors. Hence, we identified putative targets of Galangin using an in silico approach which highlighted c-Met as candidate target. Galangin effectively inhibited c-Met phosphorylation and subsequent signaling in in vitro CCA cells. In addition, Galangin was able to inhibit HGF, a mediator of c-Met signaling, by suppressing HGF-stimulated invasion, as well as migration and MMP9 activity. This shows that Galangin can be a useful anti-metastatic therapeutic strategy in a subtype of CCA patients.th
dc.language.isoen_USth
dc.subjectCholangiocarcinomath
dc.subjectท่อน้ำดี -- มะเร็งth
dc.subjectBile ducts -- Cancerth
dc.subjectโรคพยาธิใบไม้ตับth
dc.subjectLiver flukesth
dc.subjectGalanginth
dc.subjectแกลาจินth
dc.subjectยารักษามะเร็งth
dc.subjectAntineoplastic agentsth
dc.titleIn Silico Target Identification of Galangin, as an Herbal Flavonoid against Cholangiocarcinomath
dc.typeArticleth
Appears in Collections:Medical Technology - Artical Journals

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