Quantitative Determination of Favipiravir Tablets by Ultraviolet-Visible Spectrophotometry

Abstract

The objective of this study was to develop and validate a simple UV-visible spectrophotometric method for determination of favipiravir in tablet formulation. Method: Ethanol : water (1:1, v/v) was used as a solvent for the preparation of standard and sample solutions. The results showed that favipiravir exhibited the wavelength of maximum absorbance (λmax) at 227 nm. This analytical method also showed acceptable specificity, linearity, accuracy and precision. The linearity of favipiravir was noticed over the concentration range of 2 – 10 μg/mL. Similarly, the accuracy and precision results were also satisfied with average %recovery of 100.2 and %RSD of 1.28, respectively. Therefore, UV-visible spectrophotometry was suggested to be a simple, specific, accurate, and precise method for the quantification of favipiravir tablets.