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https://has.hcu.ac.th/jspui/handle/123456789/1822
Title: | Porcine placenta extract induced Akt, ERK, and JNK signaling to heighten the osteogenic activity of human osteoblasts |
Authors: | Worawat Songjang Chatchai Nensat Rutaiwan Tohtong Tuangporn Suthiphongchai Suchada Phimsen Panthip Rattanasinganchan Pornphimon Netheenukul Waraporn Kasekarn Arunya Jiraviriyakul Naresuan University. Faculty of Allied Health Sciences Thammasat University. Chulabhorn International College of Medicine Mahidol University. Faculty of Science Mahidol University. Faculty of Science Naresuan University. Faculty of Medical Science Huachiew Chalermprakiet University. Faculty of Medical Technology Kasetsart University. Faculty of Veterinary technology Naresuan University. Faculty of Medical Science Naresuan University. Faculty of Allied Health Sciences |
Keywords: | สารสกัดจากรก Placenta extract สุกร Porcine เซลล์สร้างกระดูก Osteoblasts โรคกระดูกพรุน Osteoporosis |
Issue Date: | 2022 |
Citation: | Journal of Applied Pharmaceutical Science 12,8 (August 2022) : 081-025 |
Abstract: | Porcine placenta extract (PPE) is an effective pharmaceutical and cosmetic ingredient, despite its high bioavailability. Despite this, only a few studies on the extract’s effect on human osteoblast cellular behavior have been conducted. This study used hFOB 1.19 cells to demonstrate the mechanism by which a novel potent osteogenic compound that was discovered by stimulating the growth, alkaline phosphatase secretion, mineralization, and osteogenesis markers of human osteoblast hFOB 1.19 cells resulted in significant increases in extracellular signal-regulated kinase (ERK)1/2, Akt, and c-Jun N-terminal kinase (JNK) phosphorylation. In addition, PPE was discovered to significantly increase in vitro bone formation that may provide the beneficial potential for osteoporosis prevention and treatment. |
Description: | สามารถเข้าถึงบทความฉบับเต็มได้ที่ https://japsonline.com/admin/php/uploads/3684_pdf.pdf |
URI: | https://has.hcu.ac.th/jspui/handle/123456789/1822 |
Appears in Collections: | Medical Technology - Artical Journals |
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File | Description | Size | Format | |
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Porcine-placenta-extract .pdf | 58.84 kB | Adobe PDF | View/Open |
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