Please use this identifier to cite or link to this item: https://has.hcu.ac.th/jspui/handle/123456789/1822
Title: Porcine placenta extract induced Akt, ERK, and JNK signaling to heighten the osteogenic activity of human osteoblasts
Authors: Worawat Songjang
Chatchai Nensat
Rutaiwan Tohtong
Tuangporn Suthiphongchai
Suchada Phimsen
Panthip Rattanasinganchan
Pornphimon Netheenukul
Waraporn Kasekarn
Arunya Jiraviriyakul
วรวรรษ ส่งแจ้ง
ฉัตรชัย เณรสาตร์
ฤทัยวรรณ โต๊ะทอง
ตวงพร สุทธิพงษ์ชัย
สุชาดา พิมเสน
ปานทิพย์ รัตนศิลป์กัลชาญ
พรพิมล เมธีนุกูล
วราภรณ์ เกษกาญจน์
อรัญญา จิระวิริยะกุล
Naresuan University. Faculty of Allied Health Sciences
Thammasat University. Chulabhorn International College of Medicine
Mahidol University. Faculty of Science
Mahidol University. Faculty of Science
Naresuan University. Faculty of Medical Science
Huachiew Chalermprakiet University. Faculty of Medical Technology
Kasetsart University. Faculty of Veterinary technology
Naresuan University. Faculty of Medical Science
Naresuan University. Faculty of Allied Health Sciences
Keywords: สารสกัดจากรก
Placenta extract
สุกร
Porcine
เซลล์สร้างกระดูก
Osteoblasts
โรคกระดูกพรุน
Osteoporosis
Issue Date: 2022
Citation: Journal of Applied Pharmaceutical Science 12,8 (August 2022) : 081-025
Abstract: Porcine placenta extract (PPE) is an effective pharmaceutical and cosmetic ingredient, despite its high bioavailability. Despite this, only a few studies on the extract’s effect on human osteoblast cellular behavior have been conducted. This study used hFOB 1.19 cells to demonstrate the mechanism by which a novel potent osteogenic compound that was discovered by stimulating the growth, alkaline phosphatase secretion, mineralization, and osteogenesis markers of human osteoblast hFOB 1.19 cells resulted in significant increases in extracellular signal-regulated kinase (ERK)1/2, Akt, and c-Jun N-terminal kinase (JNK) phosphorylation. In addition, PPE was discovered to significantly increase in vitro bone formation that may provide the beneficial potential for osteoporosis prevention and treatment.
Description: สามารถเข้าถึงบทความฉบับเต็มได้ที่ https://japsonline.com/admin/php/uploads/3684_pdf.pdf
URI: https://has.hcu.ac.th/jspui/handle/123456789/1822
Appears in Collections:Medical Technology - Artical Journals

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