Please use this identifier to cite or link to this item: https://has.hcu.ac.th/jspui/handle/123456789/3562
Title: Antibacterial activity of snake venoms against bacterial clinical isolates
Authors: Watcharin Rangsipanuratn
Alisa Sandee
Jureerut Daduang
Isaya Janwithayanuchit
วัชรินทร์ รังษีภาณุรัตน์
อลิสา แสนดี
จุรีรัตน์ ดาดวง
อิสยา จันทร์วิทยานุชิต
Huachiew Chalermprakiet University. Faculty of Medical Technology
Chulabhorn Research Institute
Khon Kaen University. Faculty of Associated Medical Science
Huachiew Chalermprakiet University. Faculty of Medical Technology
Keywords: Snake venoms
งูพิษ
Poisonous snakes – Venom
พิษงู
Antibacterial agents
สารต้านแบคทีเรีย
Minimum inhibitory concentration
ความเข้มข้นต่าสุดในการยับยั้งเชื้อจุลินทรีย์
Issue Date: 2019
Citation: Pharm Sci Asia 2019; 46 (2), 80-87
Abstract: Recently, many antibacterial agents have been found in the venoms of animals from different sources. However, multidrug-resistant strains of bacteria are an important health problem in need for new antibacterial sources and agents. This study aimed to evaluate the antibacterial activity of several snake crude venoms in Elapidae family against several strains of gram-positive and gram-negative bacteria as new sources of potential antibacterial agents. Current studies revealed that king cobra (Ophiophagus hannah) crude venom showed selective antibacterial activity against methicillin- resistant Staphylococcus aureus (MRSA) more efficient than tested antibiotics currently on the market. King cobra crude venom showed the minimum inhibitory concentration (MIC) = 8 µg/ml against MRSA, whereas standard antibiotics (ampicillin, penicillin, chloramphenicol and tetracycline) showed MIC in the range of 8-64 µg/ml. The result of scanning electron microscope revealed that king cobra crude venom exerted antibacterial activity against grampositive bacteria via its membrane-damaging activity and it is a feasible source for exploring antimicrobial prototypes for future design new antibiotics against drug-resistant clinical bacteria.
Description: สามารถเข้าถึงบทความฉบับเต็ม (Full Text) ได้ที่ : https://pharmacy.mahidol.ac.th/journal/_files/2019-46-2_080-087.pdf
URI: https://has.hcu.ac.th/jspui/handle/123456789/3562
Appears in Collections:Medical Technology - Artical Journals

Files in This Item:
File Description SizeFormat 
Antibacterial-activity-of-snake-venoms-against-bacterial-clinical-isolates.pdf68.25 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.