Please use this identifier to cite or link to this item: https://has.hcu.ac.th/jspui/handle/123456789/3705
Title: The Efficacy of Gynura pseudochina DC. var. hispida Thv. Ointment in Treating Chronic Plaque Psoriasis: A Randomized Controlled Trial
Authors: Pawinee Rerknimitr
Jantakan Nitinawarat
Sinee Weschawalit
Jade Wititsuwannakul
Paveena Wongtrakul
Aranya Jutiviboonsuk
Boonjeur Dhorranintra
Pravit Asawanonda
ภาวิณี ฤกษ์นิมิตร
จันทกานต์ นิติเนาวรัตน์
สินี เวศย์ชวลิต
เจตน์ วิทิตสุวรรณกุล
ปวีณา ว่องตระกูล
อรัญญา จุติวิบูลย์สุข
บุญเจือ ธรณินทร์
ประวิตร อัศวานนท์
King Chulalongkorn Memorial Hospital. Department of Medicine
Chulalongkorn University. Faculty of Medicine
Chulalongkorn University. Faculty of Medicine
Chulalongkorn University. Faculty of Medicine
Huachiew Chalermprakiet University. Faculty of Pharmaceutical Science
Huachiew Chalermprakiet University. Faculty of Pharmaceutical Science
Mahidol University. Faculty of Medicine, Siriraj Hospital
Chulalongkorn University. Faculty of Medicine
Keywords: Psoriasis -- Treatment
โรคสะเก็ดเงิน – การรักษา
Gynura pseudochina DC. var. hispida Thv -- Leaves
ว่านมหากาฬแดง – ใบ
Plant extracts
สารสกัดจากพืช
Skin -- Diseases -- Treatment
ผิวหนัง -- โรค -- การรักษา
Issue Date: 2016
Citation: J Altern Complement Med 22,8 (Aug 2016) : 669-75.
Abstract: Background: A recent study showed that Gynura pseudochina DC. var. hispida Thv. leaf extract (GP) can reduce the activation of the nuclear factor κB (NF-κB) pathway and suppress the release of interleukin (IL)-1β, IL-6, and tumor necrosis factor -α, which play an important role in the pathogenesis of psoriasis. Methods: Twenty-five patients with mild to moderate plaque psoriasis completed a 4-week trial. Twice daily, they applied the GP ointment on psoriatic lesions on one side of the body, and they applied 0.1% triamcinolone (TA) cream on the other side. The Targeted Area Score (TAS), Psoriasis Severity Index (PSI) scores, and Physician's Global Assessment (PGA) scores were assessed at baseline and at weeks 1, 2, 3, and 4. Pre- and post-treatment skin samples were taken. Phosphorylation of NF-κB p65, Ki-67, and epidermal thickness were analyzed through immunohistochemistry. Results: The TAS for erythema, scaling, and induration and PSI scores decreased on both treated sides. A statistically significant difference was observed beginning at the first week of treatment. The GP ointment significantly decreased scaling scores. However, no significant differences were observed between the TAS for erythema and induration or the PSI and PGA scores. Immunohistochemical staining revealed diminution of phosphorylated NF-κB p65, Ki-67, and epidermal thickness in the lesions treated with the GP ointment. The ointment was well tolerated, with minimal side effects. No laboratory abnormalities were detected. Conclusions: The GP ointment demonstrated efficacy similar to that of 0.1% TA cream for mild to moderate chronic plaque psoriasis. In addition, its short-term side effects were minimal.
Description: สามารถเข้าถึงบทความฉบับเต็ม (Full Text) ได้ที่ : https://pubmed.ncbi.nlm.nih.gov/27391857/
URI: https://has.hcu.ac.th/jspui/handle/123456789/3705
Appears in Collections:Pharmaceutical Sciences - Artical Journals



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