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Title: | Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model |
Authors: | Mayura Somchit Chatchawan Changtam Rungruedee Kimseng Tanyarath Utaipan Monthon Lertcanawanichakul Apichart Suksamrarn Warangkana Chunglok ณัฏฐนริน สมจิตร ชัชวาลย์ ช่างทำ รุ่งฤดี กิ้มเส้ง ธัญญรัศม์ อุทัยพันธ์ มณฑล เลิศคณาวนิชกุล อภิชาต สุขสำราญ วรางคณา จุ้งลก Walailak University. School of Allied Health Sciences and Public Health Huachiew Chalermprakiet University. Faculty of Science and Technology Walailak University. School of Allied Health Sciences and Public Health Prince of Songkla University. Faculty of Science and Technology Walailak University. School of Allied Health Sciences and Public Health Ramkhamhaeng University. Faculty of Science Walailak University. School of Allied Health Sciences and Public Health |
Keywords: | Curcuminoids เคอร์คิวมินอยด์ Diarylheptanoids ไดแอริลเฮปตานอยด์ Anti-inflammatory agents สารต้านการอักเสบ Lipopolysaccharides ลิโปโปลิย์ซัคคาไรด์ Nitric Oxide ไนตริกออกไซด์ Curcuma longa L. ขมิ้นชัน |
Issue Date: | 2014 |
Citation: | Asian Pac J Cancer Prev 2014;15(4):1807-10. |
Abstract: | It is known that inducible nitric oxide synthase (iNOS)/nitric oxide (NO) plays an integral role during intestinal inflammation, an important factor for colon cancer development. Natural compounds from Curcuma longa L. (Zingiberaceae) have long been a potential source of bioactive materials with various beneficial biological functions. Among them, a major active curcuminoid, demethoxycurcumin (DMC) has been shown to possess anti-inflammatory properties in lipopolysaccharide (LPS)-activated macrophages or microglia cells. However, the role of DMC on iNOS expression and NO production in an in vitro inflamed human intestinal mucosa model has not yet been elucidated. This study concerned inhibitory effects on iNOS expression and NO production of DMC in inflamed human intestinal Caco-2 cells. An in vitro model was generated and inhibitory effects on NO production of DMC at 65 μM for 24-96 h were assessed by monitoring nitrite levels. Expression of iNOS mRNA and protein was also investigated. DMC significantly decreased NO secretion by 35-41% in our inflamed cell model. Decrease in NO production by DMC was concomitant with down-regulation of iNOS at mRNA and protein levels compared to proinflammatory cytokine cocktail and LPS-treated controls. Mechanism of action of DMC may be partly due to its potent inhibition of the iNOS pathway. Our findings suggest that DMC may have potential as a therapeutic agent against inflammation-related diseases, especially in the gut. |
Description: | สามารถเข้าถึงบทความฉบับเต็ม (Full Text) ได้ที่ : https://pubmed.ncbi.nlm.nih.gov/24641413/ |
URI: | https://has.hcu.ac.th/jspui/handle/123456789/4267 |
Appears in Collections: | Science and Technology - Articles Journals |
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File | Description | Size | Format | |
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Demethoxycurcumin-from-Curcuma longa.pdf | 71.66 kB | Adobe PDF | View/Open |
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