Please use this identifier to cite or link to this item: https://has.hcu.ac.th/jspui/handle/123456789/4267
Title: Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model
Authors: Mayura Somchit
Chatchawan Changtam
Rungruedee Kimseng
Tanyarath Utaipan
Monthon Lertcanawanichakul
Apichart Suksamrarn
Warangkana Chunglok
ณัฏฐนริน สมจิตร
ชัชวาลย์ ช่างทำ
รุ่งฤดี กิ้มเส้ง
ธัญญรัศม์ อุทัยพันธ์
มณฑล เลิศคณาวนิชกุล
อภิชาต สุขสำราญ
วรางคณา จุ้งลก
Walailak University. School of Allied Health Sciences and Public Health
Huachiew Chalermprakiet University. Faculty of Science and Technology
Walailak University. School of Allied Health Sciences and Public Health
Prince of Songkla University. Faculty of Science and Technology
Walailak University. School of Allied Health Sciences and Public Health
Ramkhamhaeng University. Faculty of Science
Walailak University. School of Allied Health Sciences and Public Health
Keywords: Curcuminoids
เคอร์คิวมินอยด์
Diarylheptanoids
ไดแอริลเฮปตานอยด์
Anti-inflammatory agents
สารต้านการอักเสบ
Lipopolysaccharides
ลิโปโปลิย์ซัคคาไรด์
Nitric Oxide
ไนตริกออกไซด์
Curcuma longa L.
ขมิ้นชัน
Issue Date: 2014
Citation: Asian Pac J Cancer Prev 2014;15(4):1807-10.
Abstract: It is known that inducible nitric oxide synthase (iNOS)/nitric oxide (NO) plays an integral role during intestinal inflammation, an important factor for colon cancer development. Natural compounds from Curcuma longa L. (Zingiberaceae) have long been a potential source of bioactive materials with various beneficial biological functions. Among them, a major active curcuminoid, demethoxycurcumin (DMC) has been shown to possess anti-inflammatory properties in lipopolysaccharide (LPS)-activated macrophages or microglia cells. However, the role of DMC on iNOS expression and NO production in an in vitro inflamed human intestinal mucosa model has not yet been elucidated. This study concerned inhibitory effects on iNOS expression and NO production of DMC in inflamed human intestinal Caco-2 cells. An in vitro model was generated and inhibitory effects on NO production of DMC at 65 μM for 24-96 h were assessed by monitoring nitrite levels. Expression of iNOS mRNA and protein was also investigated. DMC significantly decreased NO secretion by 35-41% in our inflamed cell model. Decrease in NO production by DMC was concomitant with down-regulation of iNOS at mRNA and protein levels compared to proinflammatory cytokine cocktail and LPS-treated controls. Mechanism of action of DMC may be partly due to its potent inhibition of the iNOS pathway. Our findings suggest that DMC may have potential as a therapeutic agent against inflammation-related diseases, especially in the gut.
Description: สามารถเข้าถึงบทความฉบับเต็ม (Full Text) ได้ที่ : https://pubmed.ncbi.nlm.nih.gov/24641413/
URI: https://has.hcu.ac.th/jspui/handle/123456789/4267
Appears in Collections:Science and Technology - Articles Journals

Files in This Item:
File Description SizeFormat 
Demethoxycurcumin-from-Curcuma longa.pdf71.66 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.