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Antibacterial activity of snake venoms against bacterial clinical isolates

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dc.contributor.author Watcharin Rangsipanuratn
dc.contributor.author Alisa Sandee
dc.contributor.author Jureerut Daduang
dc.contributor.author Isaya Janwithayanuchit
dc.contributor.author วัชรินทร์ รังษีภาณุรัตน์
dc.contributor.author อลิสา แสนดี
dc.contributor.author จุรีรัตน์ ดาดวง
dc.contributor.author อิสยา จันทร์วิทยานุชิต
dc.contributor.other Huachiew Chalermprakiet University. Faculty of Medical Technology en
dc.contributor.other Chulabhorn Research Institute en
dc.contributor.other Khon Kaen University. Faculty of Associated Medical Science en
dc.contributor.other Huachiew Chalermprakiet University. Faculty of Medical Technology en
dc.date.accessioned 2025-01-25T13:58:54Z
dc.date.available 2025-01-25T13:58:54Z
dc.date.issued 2019
dc.identifier.citation Pharm Sci Asia 2019; 46 (2), 80-87 en
dc.identifier.other DOI:10.29090/psa.2019.01.018.0003
dc.identifier.uri https://has.hcu.ac.th/jspui/handle/123456789/3562
dc.description สามารถเข้าถึงบทความฉบับเต็ม (Full Text) ได้ที่ : https://pharmacy.mahidol.ac.th/journal/_files/2019-46-2_080-087.pdf en
dc.description.abstract Recently, many antibacterial agents have been found in the venoms of animals from different sources. However, multidrug-resistant strains of bacteria are an important health problem in need for new antibacterial sources and agents. This study aimed to evaluate the antibacterial activity of several snake crude venoms in Elapidae family against several strains of gram-positive and gram-negative bacteria as new sources of potential antibacterial agents. Current studies revealed that king cobra (Ophiophagus hannah) crude venom showed selective antibacterial activity against methicillin- resistant Staphylococcus aureus (MRSA) more efficient than tested antibiotics currently on the market. King cobra crude venom showed the minimum inhibitory concentration (MIC) = 8 µg/ml against MRSA, whereas standard antibiotics (ampicillin, penicillin, chloramphenicol and tetracycline) showed MIC in the range of 8-64 µg/ml. The result of scanning electron microscope revealed that king cobra crude venom exerted antibacterial activity against grampositive bacteria via its membrane-damaging activity and it is a feasible source for exploring antimicrobial prototypes for future design new antibiotics against drug-resistant clinical bacteria. en
dc.language.iso en_US en
dc.subject Snake venoms en
dc.subject งูพิษ en
dc.subject Poisonous snakes – Venom en
dc.subject พิษงู en
dc.subject Antibacterial agents en
dc.subject สารต้านแบคทีเรีย en
dc.subject Minimum inhibitory concentration en
dc.subject ความเข้มข้นต่าสุดในการยับยั้งเชื้อจุลินทรีย์ en
dc.title Antibacterial activity of snake venoms against bacterial clinical isolates en
dc.type Article en


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