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Title: | Comparison of chemical profiles, antioxidation, inhibition of skin extracellular matrix degradation, and anti-tyrosinase activity between mycelium and fruiting body of Cordyceps militaris and Isaria tenuipes |
Authors: | Adchara Prommaban Suwannee Sriyab Pachabadee Marsup Waranya Neimkhum Jakkapan Sirithunyalug Songyot Anuchapreeda Chaiwat To-anun Wantida Chaiyana อัจฉรา พรมมาแบน สุวรรณี ศรียาบ วรัญญา เนียมขำ จักรพันธ์ ศิริธัญญาลักษณ์ ทรงยศ อนุชปรีดา ชัยวัฒน์ โตอนันต์ วรรธิดา ชัยญาณะ ปชาบดี มาทรัพย์ Chiang Mai University. Faculty of Pharmacy Chiang Mai University. Faculty of Pharmacy Chiang Mai University. Faculty of Pharmacy Huachiew ChalermprakietUniversity. Faculty of Pharmaceutical Sciences Chiang Mai University. Research Center of Pharmaceutical Nanotechnology Chiang Mai University. Faculty of Associated Medical Sciences Chiang Mai University. Faculty of Agriculture Chiang Mai University. Faculty of Pharmacy |
Keywords: | คอร์ไดซิปิน Cordycepin อะดีโนซีน Adenosine อายุวัฒนะ Anti-aging ผิวหนัง -- รอยย่น Skin -- Wrinkles Anti-wrinkle |
Issue Date: | 2022 |
Citation: | Pharmaceutical Biology 60,1 (2022) : 225-234. |
Abstract: | Context Cordyceps militaris and Isaria tenuipes (Cordycipitaceae) are high-value fungi that are used for health-promoting food supplements. Since laboratory cultivation has begun for these fungi, increased output has been achieved. Objective This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of C. militaris and I. tenuipes. Materials and methods The antioxidative potential of 10% v/v aqueous infused extract from each fungus was separately investigated using 2,2-azinobis(3-ethylbenzo-thiazoline-6-sulphonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant ability, and ferric thiocyanate methods. The inhibition against MMP-1, elastase, and hyaluronidase were determined to reveal their anti-wrinkle potential. Anti-tyrosinase activities were determined. Results C. militaris and I. tenuipes extracts were found to contain a wide range of bioactive compounds, including phenolics, flavonoids, and adenosine. A correlation was discovered between the chemical compositions and their biological activities. The extract from I. tenuipes fruiting body (IF) was highlighted as an extraordinary elastase inhibitor (IC50 = 0.006 ± 0.004 mg/mL), hyaluronidase inhibitor (IC50: 30.3 ± 3.2 mg/mL), and antioxidant via radical scavenging (ABTS IC50: 0.22 ± 0.02 mg/mL; DPPH IC50: 0.05 ± 0.02 mg/mL), thereby reducing ability (EC1: 95.3 ± 4.8 mM FeSO4/g extract) and lipid peroxidation prevention (IC50: 0.40 ± 0.11 mg/mL). IF had a three-times higher EC1 value than ascorbic acid and significantly higher elastase inhibition than epigallocatechin gallate. Discussion and conclusions IF is proposed as a powerful natural extract with antioxidant and anti-wrinkle properties; therefore, it is suggested for further use in pharmaceutical, cosmeceutical, and nutraceutical industries. |
Description: | สามารถเข้าถึงบทความฉบับเต็มได้ที่ https://www.tandfonline.com/doi/epdf/10.1080/13880209.2021.2025255?needAccess=true |
URI: | https://has.hcu.ac.th/jspui/handle/123456789/1829 |
Appears in Collections: | Pharmaceutical Sciences - Artical Journals |
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Cordycepin.pdf | 60.17 kB | Adobe PDF | View/Open |
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