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https://has.hcu.ac.th/jspui/handle/123456789/3669| Title: | Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves |
| Authors: | Songyot Anuchapreeda Riki Anzawa Natsima Viriyaadhammaa Waranya Neimkhum Wantida Chaiyana Siriporn Okonogi Toyonobu Usuki ทรงยศ อนุชปรีดา วรัญญา เนียมขำ วรรธิดา ชัยญาณะ ศิริพร โอโกโนกิ Chiang Mai University. Faculty of Associated Medical Sciences Sophia University. Faculty of Science and Technology (Tokyo) Chiang Mai University. Faculty of Associated Medical Sciences Huachiew Chalermprakiet University. Faculty of Pharmaceutical Sciences Chiang Mai University. Faculty of Pharmacy Chiang Mai University. Faculty of Pharmacy Sophia University. Faculty of Science and Technology (Tokyo) |
| Keywords: | Anticancer ยารักษามะเร็ง Antioxidants แอนติออกซิแดนท์ Anti-inflammatory agents สารต้านการอักเสบ Antibiotics แอนติบอดีย์ Bioactive compounds สารออกฤทธิ์ทางชีวภาพ Citrus hystrix -- Leaves มะกรูด – ใบ Kaffir lime Agrostophillinol |
| Issue Date: | 2020 |
| Citation: | Bioorg Med Chem Lett 2020 Jul 15;30(14):127256 |
| Abstract: | The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from a hexane fractional extract and identified as agrostophillinol. This is the first report of agrostophillinol isolated from kaffir lime leaves. In terms of cytotoxicity, agrostophillinol exhibited IC50 values of 36.27 ± 7.30 and 53.44 ± 10.63 μg/mL against EoL-1 and HL60 cells, respectively. Agrostophillinol also exhibited potent anti-inflammatory activity, significantly inhibiting IL-6 secretion. |
| Description: | สามารถเข้าถึงบทความฉบับเต็ม (Full Text) ได้ที่ : https://pubmed.ncbi.nlm.nih.gov/32527555/ |
| URI: | https://has.hcu.ac.th/jspui/handle/123456789/3669 |
| Appears in Collections: | Pharmaceutical Sciences - Artical Journals |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Isolation-and-biological-activity-of-agrostophillinol.pdf | 70.01 kB | Adobe PDF | View/Open |
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