A general method for the synthesis of substituted (1E,4E,6E)-1,7-diphenylhepta-1,4,6-trien-3-ones, based on the aldol condensations of substituted 4-phenylbut-3-en-2-ones and substituted 3-phenylacrylaldehydes, was achieved. ...
Amyloid-β peptides (Aβ), a major component of senile plaques, play an important role in the development and progression of Alzheimer's disease. Several lines of evidence have demonstrated that Aβ-induced neuronal death is ...
Endoplasmic reticulum (ER) stress is involved in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Therefore, interventions that attenuate ER stress may contribute to induction in apoptotic ...
Thalassemia is an inherited disorder of hemoglobin molecules that is characterized by an imbalance of α- and β-globin chain synthesis. Accumulation of unbound α-globin chains in erythroid cells is the major cause of pathology ...
An optimal design procedure for bulk modified atmosphere packaging (MAP) that would enable the long-term storage of ‘Fuyu’ persimmon fruit for export market was proposed in this study. Initially, the lower O2 limit of ...
A reaction of a ligand 3,3′-(1,4-butanediyldinitrilo)bis(2-butanone)dioxime (BnH2 ) and CuCl yield green [Cu(H2 dmg)Cl(μ-Cl)]2 ,1. The dimethylglyoxime (H2 dmg) and CuIIions in 1 were in situ produced during the course of ...
This study was designed to examine the vasorelaxant effects of hexahydrocurcumin (HHC), one of the major natural metabolites of curcumin from Curcuma longa, on rat isolated aortic rings, and the underlying mechanisms. ...
It is known that inducible nitric oxide synthase (iNOS)/nitric oxide (NO) plays an integral role during intestinal inflammation, an important factor for colon cancer development. Natural compounds from Curcuma longa L. ...
Tetrahydrocurcumin (THC) is a stable metabolite of curcumin (CUR) in physiological systems. The mechanism underlying the anticancer effect of THC is not completely understood. In the present study, we investigated the ...
Background: Tetrahydrocurcumin (THC) demonstrated an anti-cancer and anti-angiogenic effects in cervical cancer. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, have also shown anticancer effect. However, the ...
The natural curcuminoids, curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), have been structurally modified to the demethylated analogues 4-6, methylated analogues 7-12, acetylated analogues ...
Objectives: Phosphodiesterase (PDE)-5 inhibitors are useful as vasodilators for the treatment of pulmonary arterial hypertension. We aimed to study curcumin analogues for PDE5 inhibitory activity and vasorelaxation of rat ...
Alzheimer's disease (AD) is a neurodegenerative and progressive disorder. The hallmark of pathological AD is amyloid plaque which is the accumulation of amyloid β (Aβ) in extracellular neuronal cells and neurofibrillary ...
Mathuros Ornthai; Atitaya Siripinyanond; Bruce K. Gale; มธุรส อ่อนไทย; อทิตยา ศิริภิญญานนท์(2016)
A major limitation of electrical field-flow fractionation (ElFFF) is the polarization of the electrodes that occurs when using an ionic carrier liquid. As there is great interest in using ElFFF with biological materials ...
Background: Targeting inflammatory macrophages and their products is an effective method for controlling inflammation. The pyrazole analog of curcumin (curcumin pyrazole, PYR) has been reported to possess superior ...
The effect of hot water treatment on microbiological quality of fresh-cut 'Kimju' and 'Pan Srithong' guava was investigated. Guava fruit, cv. 'Kimju' and 'Pan Srithong' were treated with hot water at 40, 50 and 60°C for ...
A novel alkaline lipase was purified and characterized from Pseudomonas sp. HCU2-9. The lipase was purified to homogeneity using ammonium sulphate precipitation and gel filtration chromatography. The molecular weight of ...